Using Auto Layout with UIScrollView is surprisingly simple. You just need to add constraints to the content that will fill the entire scrollview by anchoring to the 4 edges of the scroll view. You don't need to set the content size of the scroll view explicitly. This is because the 4 edges actually refer to the scroll view's content view rather than the scroll view itself.

let scrollView = UIScrollView()
content.translatesAutoresizingMaskIntoConstraints = false

let content = UIView()
//TODO: Set up `content`, adding subviews, etc
content.translatesAutoresizingMaskIntoConstraints = false
scrollView.addSubview(content)

NSLayoutConstraint.activate([
    content.leadingAnchor.constraint(equalTo: scrollView.leadingAnchor),
    content.trailingAnchor.constraint(equalTo: scrollView.trailingAnchor),
    content.topAnchor.constraint(equalTo: scrollView.topAnchor),
    content.bottomAnchor.constraint(equalTo: scrollView.bottomAnchor),

    //Of course you'll want to layout the scrollview itself. Likely occupying the entire parent
    scrollView.leadingAnchor.constraint(equalTo: view.leadingAnchor),
    scrollView.trailingAnchor.constraint(equalTo: view.trailingAnchor),
    scrollView.topAnchor.constraint(equalTo: view.topAnchor),
    scrollView.bottomAnchor.constraint(equalTo: footerBar.topAnchor),

    //TODO set up constraints for `content` as you would have if there was no `UIScrollView` involved
])

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